Description
MetaXL keeps pushing the envelope of innovation in meta-analysis. Version 1 introduced the quality effects (QE) model, version 2 the inverse variance heterogeneity (IVhet) model, version 3 introduced the Doi plot and LFK index for the detection of publication bias, version 4 added network meta-analysis. Now version 5 adds cumulative meta-analysis to this already rich list of features
Meta-analysis is a statistical method to combine the results of epidemiological studies in order to increase power. Basically, it produces a weighted average of the included studies results.
There are two main issues with meta-analysis: heterogeneity between studies, and publication bias. Heterogeneity is usually dealt with by employing the random effects (RE) model. However the RE estimator, as explained in the MetaXL User Guide, underestimates the statistical error and has a larger mean squared error (MSE) than even the fixed effects estimator. It also makes unjustifiable changes to study weights. For these reasons it is seriously flawed and should be abandoned. MetaXL offers two alternatives to the RE model:
1) The IVhet model provides a quasi-likelihood based expansion of the confidence interval around the inverse variance weighted pooled estimate when studies exhibit heterogeneity (without inappropriate changes to individual study weights, as the random effects model does), thus keeping the MSE lower than with the random effects estimator.
2) The QE model allows incorporating information on study quality into the analysis, thereby affording the opportunity for further reduction in estimator MSE beyond that of the IVhet model. Much of the heterogeneity between study results is explained by differences in study quality, and it is preferable to make use of this information explicitly.
More background on these alternatives is in our publications.
Publication bias can occur, among other reasons, because studies with ‘positive' results are more likely to get published than ones with ‘negative' results. Traditionally, the funnel plot is used to detect possible publication bias, but this plot is often hard to interpret. MetaXL now offers an alternative, the Doi plot, which is much easier to interpret.
Network meta-analysis can make multiple indirect comparisons, thus allowing to assess a range of treatment options against a common comparator. It is a powerful technique, but it has been held back by complex methods. The MetaXL implementation is powerful, yet very easy to use.
Cumulative meta-analysis allows to analyse how the evidence evolved over time.
Using Excel as a platform makes MetaXL-based meta-analysis highly accessible. And you still can't beat the price!
~~~
RevMan 5 is the desktop version of the software used for other review formats (diagnostic, methodology, overviews), for non-Cochrane reviews, and for offline working. You can use RevMan 5 alongside RevMan Web if needed.
- Stats made simple. Jamovi is a new '3rd generation' statistical spreadsheet. Designed from the ground up to be easy to use, jamovi is a compelling alternative to costly statistical products such as SPSS and SAS.
- Working with RevMan 5 (Review Manager) Cochrane's RevMan 5 (Review Manager) software is freely available to download for Cochrane authors and for academic and non-commercial use. The RevMan user guide provides useful guidance for all users. Non-Cochrane users. Please ensure you are running RevMan in Non-Cochrane mode. This allows RevMan to run.
IMPORTANT UPDATE -- 04/06/2019
A recent glitch has been discovered whereby two separate sets of studies with the exact same pooled effect size and standard error produce Doi plots and LFK indexes that do not overlap with each other. This is due to an error in the ranking calculation within MetaXL. This glitch only occurs when the same effect size and standard error are observed across different sets of studies.
A Stata ado file has been developed to generate a Doi plot and LFK index without the glitch. This can be accessed by downloading LFK Stata package v1.zip. The downloaded file contains: (1) a Stata ado file implementing the fix; (2) a Stata help file; and (3) a PDF which describes the problem in full and provides accompanying installation instructions.
Please note that this fix is an alpha version as it only deals with the IOType parameters: ContSE; NumOR; and NumRR.
A link is provided to the Documentation Index page of the Cochrane Informatics & Knowledge Management Department, where you can find further information and materials relating to RevMan. RevMan 5 and Data extraction. Download RevMan 5 1. Download the installation file (Windows. • Only one person at a time can check out a draft into RevMan. Download Review Manager 5.3.5 from our website for free. The most popular versions among Review Manager users are 5.3, 5.2 and 5.1. This download was scanned by our built-in antivirus and was rated as virus free.
Revman Download Mac Version
Description
MetaXL keeps pushing the envelope of innovation in meta-analysis. Version 1 introduced the quality effects (QE) model, version 2 the inverse variance heterogeneity (IVhet) model, version 3 introduced the Doi plot and LFK index for the detection of publication bias, version 4 added network meta-analysis. Now version 5 adds cumulative meta-analysis to this already rich list of features
Meta-analysis is a statistical method to combine the results of epidemiological studies in order to increase power. Basically, it produces a weighted average of the included studies results.
There are two main issues with meta-analysis: heterogeneity between studies, and publication bias. Heterogeneity is usually dealt with by employing the random effects (RE) model. However the RE estimator, as explained in the MetaXL User Guide, underestimates the statistical error and has a larger mean squared error (MSE) than even the fixed effects estimator. It also makes unjustifiable changes to study weights. For these reasons it is seriously flawed and should be abandoned. MetaXL offers two alternatives to the RE model:
1) The IVhet model provides a quasi-likelihood based expansion of the confidence interval around the inverse variance weighted pooled estimate when studies exhibit heterogeneity (without inappropriate changes to individual study weights, as the random effects model does), thus keeping the MSE lower than with the random effects estimator.
2) The QE model allows incorporating information on study quality into the analysis, thereby affording the opportunity for further reduction in estimator MSE beyond that of the IVhet model. Much of the heterogeneity between study results is explained by differences in study quality, and it is preferable to make use of this information explicitly.
More background on these alternatives is in our publications.
Publication bias can occur, among other reasons, because studies with ‘positive' results are more likely to get published than ones with ‘negative' results. Traditionally, the funnel plot is used to detect possible publication bias, but this plot is often hard to interpret. MetaXL now offers an alternative, the Doi plot, which is much easier to interpret.
Network meta-analysis can make multiple indirect comparisons, thus allowing to assess a range of treatment options against a common comparator. It is a powerful technique, but it has been held back by complex methods. The MetaXL implementation is powerful, yet very easy to use.
Cumulative meta-analysis allows to analyse how the evidence evolved over time.
Using Excel as a platform makes MetaXL-based meta-analysis highly accessible. And you still can't beat the price!
~~~
RevMan 5 is the desktop version of the software used for other review formats (diagnostic, methodology, overviews), for non-Cochrane reviews, and for offline working. You can use RevMan 5 alongside RevMan Web if needed.
- Stats made simple. Jamovi is a new '3rd generation' statistical spreadsheet. Designed from the ground up to be easy to use, jamovi is a compelling alternative to costly statistical products such as SPSS and SAS.
- Working with RevMan 5 (Review Manager) Cochrane's RevMan 5 (Review Manager) software is freely available to download for Cochrane authors and for academic and non-commercial use. The RevMan user guide provides useful guidance for all users. Non-Cochrane users. Please ensure you are running RevMan in Non-Cochrane mode. This allows RevMan to run.
IMPORTANT UPDATE -- 04/06/2019
A recent glitch has been discovered whereby two separate sets of studies with the exact same pooled effect size and standard error produce Doi plots and LFK indexes that do not overlap with each other. This is due to an error in the ranking calculation within MetaXL. This glitch only occurs when the same effect size and standard error are observed across different sets of studies.
A Stata ado file has been developed to generate a Doi plot and LFK index without the glitch. This can be accessed by downloading LFK Stata package v1.zip. The downloaded file contains: (1) a Stata ado file implementing the fix; (2) a Stata help file; and (3) a PDF which describes the problem in full and provides accompanying installation instructions.
Please note that this fix is an alpha version as it only deals with the IOType parameters: ContSE; NumOR; and NumRR.
A link is provided to the Documentation Index page of the Cochrane Informatics & Knowledge Management Department, where you can find further information and materials relating to RevMan. RevMan 5 and Data extraction. Download RevMan 5 1. Download the installation file (Windows. • Only one person at a time can check out a draft into RevMan. Download Review Manager 5.3.5 from our website for free. The most popular versions among Review Manager users are 5.3, 5.2 and 5.1. This download was scanned by our built-in antivirus and was rated as virus free.
Revman Download Mac Version
Thank you for using our software portal. To download the product you want for free, you should use the link provided below and proceed to the developer's website, as this is the only legal source to get Review Manager.
However, we must warn you that downloading Review Manager from an external source releases FDM Lib from any responsibility. Please carefully check your downloads with antivirus software. FDM Lib shall include an option for direct download from developers, should it become available in the future.
What Is Revman
RevMan 5 is available for download as locally installed software (current version: 5.3.5). Please ensure you read the below instructions carefully before downloading. • If you encounter any issues during the installation process, please refer to the before contacting the. • We can only offer to registered Cochrane authors. If you are not yet active with a Cochrane Group, but would like to become involved, you can. • Please report any problems you find using 'Report a problem' in the Help menu of RevMan 5 or through the. Step 1: Download the installation file Download the file that matches your operating system: Windows Linux Mac OS X 32 bit version - will work on all Windows machines 64 bit version - will only work on 64 bit Windows machines Java 8 version for OS X 10.13 (High Sierra) and higher with bundled Java 8 Java 7 version f or OS X 10.7.2 (Lion) and higher with bundled Java 7 *** Java 6 version for OS X 10.5 (Leopard) on Intel CPU or 10.6 (Snow Leopard) *** Note: We have discovered some issues running RevMan under Java 7.
Before installing this version, we recommend first downloading the on your Mac and try the RevMan version for Java 6. Step 2: Run the installer Important: You need to be using an account that has sufficient permission to install software on the computer.
Ea installer cleanup download. Relative to the overall usage of users who have this installed on their PCs, most are running Windows 7 (SP1) and Windows 10. The setup package generally installs about 91 files and is usually about 6.66 MB (6,979,912 bytes). While about 16% of users of FIFA 14 come from Germany, it is also popular in the United States and Brazil.
Revman 5 Download
Note for OS X users: The most recent versions of OS X do not come with Java included; you will automatically be prompted to install Java before continuing with the RevMan 5 installation. Note for Linux users: • RevMan's automatic update feature may only work fully if you are installing the software as the root user. Step 3: Go through the installation wizard Step 4: Run RevMan 5 You can now begin using RevMan 5. If you encounter any issues when downloading and installing RevMan, please see our. Previous versions Please contact if you require a previous version of RevMan 5.
